ETHYL(3-HYDROXY-1-METHYLBUTYL)BARBITURIC ACIDS AS METABOLITES OF PENTOBARBITAL

Ethyl (3-hydroxy-1-methylbutyl) barbituric acids as metabolites of pentobarbital.

Despite abundant pharmacological research on the 5,5-dialkylbarbituric acids, their metabolic fate has not been elucidated. Earlier studies (2, 3) from this laboratory proved that pentobarbital and Amytal are not detoxified by simple hydrolysis of the barbituric acid ring. The present report describes further experiments with isotopic pentobarbital which led to the isolation and characterizatio...

Synthesis of 1-Hydroxy-2-(Prop-2'-Enyl) 9-Antrone

An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On ...

Alpha Hydroxy Acids in Cosmetic Dermatology

Efficient Synthesis of a Range of 1-Hydroxy-2-(1-Alkyloxymethyl)-9,10-Anthraquinone Derivatives

Five new 1-hydroxy-2-(1-alkyloxymethyl)-9,10-Anthraquinones (9a-e) have been prepared. Selective nitration of 2-methyl-9,10-anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-2-methyl-9,10-anthraquinone in good yield as the key intermediate. Reaction with dimethylsulphate/K2CO3 and subsequen...